Transcriptional reprogramming of kidney tubules
نویسندگان
چکیده
منابع مشابه
Kidney Cortex Tubules
Triacylglycerol metabolism has been studied in kidney cortex tubules from starved rats, prepared by collagenase treatment. Triacylglycerol was determined by a newly developed fully enzymic method. Incubation of tubules in the absence of fatty acids led to a decrease of endogenous triacylglycerol by about 50% in 1 h. Addition of albuminbound oleate or palmitate resulted in a steady increase of t...
متن کاملKidney Proximal Tubules
The aim of this study was to evaluate the role of the kidney in mediating the signals involved in adaptive changes in luminal Na+/H+ exchange and basolateral Na+:HCOcotransport systems in metabolic acidosis. Proximal tubular suspensions were prepared from rabbit kidney cortex and incubated in acidic (A) or control (C) media (pH 6.9 vs 7.4, 5% C02) for 2 h. Brush border membrane (BBM) and basola...
متن کاملTranscriptional adaptation to Clcn5 knockout in proximal tubules of mouse kidney.
Dent disease has multiple defects attributed to proximal tubule malfunction including low-molecular-weight proteinuria, aminoaciduria, phosphaturia, and glycosuria. To understand the changes in kidney function of the Clc5 chloride/proton exchanger gene knockout mouse model of Dent disease, we examined gene expression profiles from proximal S1 and S2 tubules of mouse kidneys. We found many chang...
متن کاملTranscriptional reprogramming in cellular quiescence
Most cells in nature are not actively dividing, yet are able to return to the cell cycle given the appropriate environmental signals. There is now ample evidence that quiescent G0 cells are not shut-down but still metabolically and transcriptionally active. Quiescent cells must maintain a basal transcriptional capacity to maintain transcripts and proteins necessary for survival. This implies a ...
متن کاملProgress in microelectrode techniques for kidney tubules.
Altlhoughi microelectrocle measurements lhave caused a good deal of confusion in the investigation of renal electrolyte transport (for literature see Ref. 4), we cannot do witlhout them. Knowledge of the electrical potential steps, whiclh the ions have to pass (luring their reabsorption, is indispensable for understanding the transport meclhanisms involved. Hence the development of more reliabl...
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ژورنال
عنوان ژورنال: Nature Reviews Nephrology
سال: 2016
ISSN: 1759-5061,1759-507X
DOI: 10.1038/nrneph.2016.166